"The only really stupid thing I ever did in my life was to start smoking," he said in 1996. Seeing people smoking in television and films, he added, "disgusts me, it makes me so angry — kids are watching."
In his later years, he guest-starred on TV series including "Third Watch" and "Crossing Jordan" and appeared in a 2010 theatrical film, "Camera Obscura."
Klugman's hobby was horse racing and he eventually took up raising them, too.
A horse Klugman co-owned, Jacklin Klugman, finished third in 1980's Kentucy Derby and fourth in that year's Preakness Stakes.
"I always loved to gamble," he said. "I never got close to a horse. Fate dealt me a terrible blow when it gave me a good horse the first time out. I thought how easy this is.
"Now I love being around them."
Klugman's wife, actress-comedian Brett Somers, played his ex-wife, Blanche, in the "Odd Couple" series. The couple, who married in 1953 and had two sons, Adam and David, had been estranged for years at the time of her death in 2007.
In February 2008, at age 85, Klugman married longtime girlfriend Peggy Crosby. His attorney Larry Larson wrote in an email that Klugman is also survived by two grandchildren and that memorial services have not been set.
In 1997, Klugman was sued by an ex-girlfriend, Barbara Neugass, who claimed he had promised to support her for the rest of her life. But a jury rejected her claim.
Biographical material in this story was written by former AP staffer Polly Anderson.