Lewis, Danes' co-star, took note of "Breaking Bad" star Bryan Cranston, winner of three best actor Emmys who had been trying for a fourth on Sunday.
"I was quite convinced he would be walking up tonight," he said.
Along with the awards, there were a few cultural moments that lit up social media and will be water-cooler fodder as TV fans head back to work:
— Danes' odd "Mandy Patinkin, holla!" tribute to her fellow actor.
— Host Jimmy Kimmel and Tracy Morgan conspiring to start a rumor that Morgan had passed out onstage.
— Curve-accentuating dresses worn by the likes of Kat Dennings of "2 Broke Girls," Sofia Vergara of "Modern Family" and Christina Hendricks of "Mad Men."
— Jon Stewart punctuating his acceptance speech with an f-bomb, resulting in the only bleep of the evening.
Stewart's "The Daily Show" is one of the Emmy Awards' sure things. It won the award for best variety show for the 10th straight year. CBS' "The Amazing Race" won its ninth award for best reality show in 10 years.
Probably the least-predicted winner was Jon Cryer of CBS' "Two and a Half Men" as best comic actor. He's won the best supporting actor award in the past as second banana to Charlie Sheen. But with Ashton Kutcher replacing Sheen in the cast last season, Cryer moved up in class. Even he was taken aback by the win, saying he figured two-time trophy winner Jim Parsons of "The Big Bang Theory" would get it.
"Don't panic, people. Something has clearly gone terribly wrong. I'm stunned," Cryer said after the award was announced.
HBO's freshman comedy "Veep" received mixed reviews, but Emmy voters loved veteran actress Julia Louis-Dreyfus, who won the best comedy actress award for her turn as a caustic U.S. vice president.