Elijah Pittman scored 31 points and Ryan Taylor grabbed 10 rebounds to lift Marshall over South Carolina State in the season opener.
Pittman hit one of his five 3-pointers at the 8:28 mark of the first half to give Marshall a 23-21 lead and the Thundering Herd never trailed again, forcing 18 turnovers that produced 23 points.
Taylor added 17 points for Marshall and Kareem Canty added 15 and five assists.
Matthew Hezekia led the Bulldogs with 19 points and was their only player in double figures.
South Carolina State kept the game close well into the first half but got worn down by turnovers and a Marshall defense that made 12 steals and eight blocked shots.
The Bulldogs also committed 29 fouls.