He dodged few questions and refused to implicate anyone else, even as he said it was humanly impossible to win seven straight Tours without doping.
"I'm not comfortable talking about other people," Armstrong said. "I don't want to accuse anybody."
Whether his televised confession will help or hurt Armstrong's bruised reputation and his already-tenuous defense in at least two pending lawsuits, and possibly a third, remains to be seen. Either way, a story that seemed too good to be true — cancer survivor returns to win one of sport's most grueling events seven times in a row — was revealed to be just that.
"This story was so perfect for so long. It's this myth, this perfect story, and it wasn't true," he said.
Winfrey got right to the point when the interview began, asking for yes-or-no answers to five questions.
Did Armstrong take banned substances? "Yes."
Did that include the blood-booster EPO? "Yes."
Did he do blood doping and use transfusions? "Yes."
Did he use testosterone, cortisone and human growth hormone? "Yes."
Did he take banned substances or blood dope in all his Tour wins? "Yes."
In his climb to the top, Armstrong cast aside teammates who questioned his tactics, yet swore he raced clean and tried to silence anyone who said otherwise. Ruthless and rich enough to settle any score, no place seemed beyond his reach — courtrooms, the court of public opinion, even along the roads of his sport's most prestigious race.
That relentless pursuit was one of the things that Armstrong said he regretted most.
"I deserve this," he said twice.
"It's a major flaw, and it's a guy who expected to get whatever he wanted and to control every outcome. And it's inexcusable. And when I say there are people who will hear this and never forgive me, I understand that. I do. ...